Moracin C

Research use only, not for human use.

Moracin C, a natural compound found in Morus mesozygia, Morus alba var. multicaulis, is an anti-inflammatory agent.

Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells.

RT-PCR Cell Line:RAW 264.7 macrophages Concentration:1, 10, 25, 50 μM Incubation Time:2 h Result:Inhibited LPS-induced mRNA expression of iNOS and COX-2.Western Blot Analysis Cell Line:RAW 264.7 macrophages Concentration:1, 10, 25, 50 μM Incubation Time:2 h Result:Inhibited LPS-induced TLR4 expression and NF-κB activation.Reduced phosphorylated p38, ERK and JNK levels.

Animal Model:Mice (PK Assay)Dosage:100 mg/kg Administration:Oral gavage Result:Pharmacokinetic profile of Moracin C.

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Immunology/Inflammation

ROS

ROS | NO Synthase

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69120-06-5

310.34

C19H18O4

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (805.57 mM; Ultrasonic )

CC(C)=CCc1c(O)cc(cc1O)-c1cc2ccc(O)cc2o1

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(-20℃)

With Ice Pack

≥ 2 years